The Ural-375S is a semi-trailer tractor based on the Ural-375 and produced by the UralAZ from 1961 to 1964. After the 1964 series update, this model will transition to the Ural-375S-K1, just to be renamed Ural-375S later in the 1970s.

It had a fifth wheel coupling and one or two spare wheels. It obviously had the soft top and foldable windshield.

• Engine:
  • ZIL-135
• Drivetrain: 6×6

In 1964, following the series update, the Ural-375S-K1 model will be produced as a transitional model.