The Ural-375E is another chassis cab version of the Ural-375D designed for installation of various specialized bodies including vans. It was designed alongside the Ural-375D and Ural-375A and shares production years.

It was identical to the Ural-375D except no body was mounted on it.

• Engine:
  • ZIL-375
• Drivetrain: 6×6

In 1982, the Ural-375E received the series update and became the Ural-375EM.